Covid-19 Antibody Development at Precision Antibody

COLUMBIA, Maryland, August 31, 2020: A&G Pharmaceutical, Inc (A&G), with its Custom Antibody Division Precision Antibody has developed mouse monoclonal antibodies (mAbs) against COVID-19 antigens; Spike protein S1 and nucleocapsid protein (N-protein).

Anti-SARS-Cov2 S1 protein (non RBD) mAbs:

  • Available antibodies recognize the S1 protein outside of the RBD region.
  • COVID-19-specific (SARS-Cov2) and do not cross-react to SARS Cov1 (SARS Cov 2003) and MERS.
  • Recognize the trimeric form of Cov-2 S1 protein similarly or better than the S1 monomer.
  • Our anti-S1 and anti-RBD antibodies bind with high affinity to non-overlapping epitopes*, making them compatible with sandwich ELISA or lateral flow applications.
  • Several selected antibodies can be used on Protein Simple Wes, on Western blot and for immunoprecipitation.

Anti-SARS-Cov2 RBD protein mAbs:

  • Available antibodies recognize the RBD region of the S1 proteinmAbs are COVID-19-specific (SARS-Cov2) and do not cross-react to SARS Cov1 (SARS Cov 2003) and MERS.
  • Recognize the trimeric form of Cov-2 S1 protein similarly or better than the S1 monomer.
  • Our anti-RBD antibodies bind with high affinity to non-overlapping epitopes*, making them compatible with sandwich ELISA or lateral flow applications.
  • Several selected antibodies can be used on Protein Simple Wes, on Western blot and for immunoprecipitation.

Anti-SARS-Cov2 nucleocapsid protein mAbs:

Selected antibodies have the following properties

  • All selected antibodies bind equally well in the presence of 1% Triton X100
  • Our anti-N protein antibodies bind with high affinity to non-overlapping epitopes*, making them compatible with sandwich ELISA or lateral flow applications.
  • Selected antibodies can be used on Protein Simple Wes, on Western blot and for immunoprecipitation.

*As determined by Scouting and Epitope binning assays

Our Anti-Human ACE2 protein mAbs:

  • Selected antibodies can be used on sandwich EIA Western blot and for immunoprecipitation.

All the Anti-S1 protein, Anti-RBD, Anti-N protein, and Anti-Human ACE2 Protein mAbs are available for purchase at store.precisionantibody.com/antibodies 

Precision Antibody has also developed Neutralizing mouse Monoclonal Antibodies and Fully Human monoclonal Antibodies against Sars-CoV-2. For more information about our Neutralizing mAbs and our Fully Human Covid-19 mAbs, please contact Dr. Jun Hayashi (jhayashi@precisionantibody.com)

 

For any inquiries about the catalog antibodies or another potential custom antibody projects, please contact:

Keenan Doubleday
Sales Manager, Precision Antibody
kdoubleday@precisionantibody.com


Sarah Hayashi
Project Manager, Precision Antibody
shayashi@precisionantibody.com

 

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