Fully Human Monoclonal Antibody Development
Precision Antibody is setting a NEW STANDARD:
Fully Human MAB (Monoclonal Antibody) Development in ~60 Days!
Accelerating Antibody Drug Development to a New Level
Projects are discussed with our scientists from the start and are milestone-based.
Precision Antibody offers the following related services:
- Variable region sequence determination of human antibodies using MiSeq.
- Cell line development.
- Production up to gram quantities of antibodies.
- Anti-ID development for PK and ADA assays.
- Reverse engineering of human antibodies to generate mouse monoclonal counterpart.
Start Your Fully Human Monoclonal Antibody Development Project!
Start your antibody development program with Precision Antibody’s fully human monoclonal antibody development platform. Our scientists work closely with you from project initiation through key milestones to ensure your antibody meets the required specificity, affinity, and functional performance. Whether you are at the early target validation stage or ready for lead generation, our rapid ~60-day development timeline can significantly shorten your path to preclinical success.
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Fully human monoclonal antibody development
Precision Antibody has established an exclusive service arrangement with Trans Chromosomics (TC) to introduce a new service of developing Fully Human Monoclonal Antibody in 60 DAYS.
The antibody drug development is a lengthy process spanning target discovery, target validation, lead generation, preclinical studies to clinical trials. With the use of TC mice, we can significantly shorten the time for lead generation saving up to two years in the antibody generation services.
To obtain human functional antibodies (neutralizing, internalizing, or agonistic) with desired affinity, the use of humanized mice to develop fully human monoclonal antibodies offers several advantages over the other methods.
TC mice stand out from the other commercialized humanized mice on the market for its significantly high degree of immunocompetence.
- The ability to develop fully human IgG by immunization. Antibodies developed with almost all other humanized mice will require further humanization.
- The ability to mount strong immune response to the immunogen in short period of time (21 days). Many humanized mice do not mount good immune response required for the development of antibodies with desired specificity and function.
- The ability to generate B cell repertoire closely resembling normal human repertoire as seen by the fact that the average length of CD3RH and amino-acid usage obtained with TC mice are similar to human PBMC (see Figure, above).
- The ability to generate a large number of antigen-specific B cell population.
- The ability to produce expanded antigen-specific B cell population.
- The ability to generate many hybridoma cells producing antigen-specific fully human IgG in a short period of time (~60 days: see Table, above).
Monoclonal ab Production Services
Precision Antibody provides end-to-end monoclonal antibody production services designed to support discovery, preclinical development, and translational research. From fully human monoclonal antibody generation using advanced Trans Chromosomics (TC) mouse technology to scalable antibody expression and purification, our integrated workflows ensure high-quality antibodies with defined specificity, affinity, and functionality.
As a trusted monoclonal antibody service provider, we support a wide range of applications including therapeutic antibody development, PK and ADA assay support, and antibody engineering or reverse engineering. Our ability to rapidly generate fully human IgG, combined with production capabilities up to gram quantities, allows researchers and biotech teams to accelerate timelines while reducing risk and downstream re-engineering.
Partner with Precision for Your Antibody Needs
Experience a dedicated approach to custom antibodies with unmatched expertise, fast delivery, and personalized service. Let’s collaborate to bring your research to life.
Disclaimer:
All clones developed are the customer’s property.
Precision Antibody does not retain any ownership.
We are happy to exchange CDA, NDA, & MSA.
Contact us for your next Fully human monoclonal antibody development project
For inquiries about your next Fully Human Monoclonal Antibody Generation project, please call us, email us, or use our online quote request form for a free consultation and pricing.
- 410-884-4100
- 410-884-1607
- orders@precisionantibody.com
- 9130 Red Branch Road, Suite X, Columbia, MD 21045
- Mon-Fri 9:00AM – 5:00PM
Benefits
- Dedicated Project Manager
- AAALAC Accredited/USA Lab
- Timeline – Rapid Timeline 60 days
- Milestone Based Invoicing/IP Free
